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Sex difference in mouse embryonic development at neurulation.

M J Seller, K J Perkins-Cole

    Journal of Reproduction and Fertility
    |January 1, 1987
    PubMed
    Summary
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    Early mouse embryos show sex-based developmental differences. Female embryos were less developed, while male embryos were more advanced, indicating sex-linked variations during neurulation.

    Area of Science:

    • Developmental Biology
    • Embryology
    • Genetics

    Background:

    • Neurulation is a critical developmental process in early embryogenesis.
    • Sex determination influences various biological processes, including development.

    Purpose of the Study:

    • To investigate potential sex-based differences in the developmental stages of mouse embryos during early neurulation.
    • To analyze the relationship between embryonic development stage and sex.

    Main Methods:

    • Collection of 67 mouse embryos from 10 litters at Day 9 of gestation.
    • Classification of embryos based on precise developmental stage.
    • Sex-chromatin analysis performed on yolk sac tissue.

    Main Results:

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  • Within litters, less developed embryos were more frequently female.
  • More advanced embryos within litters were predominantly male.
  • Overall, male embryos exhibited a higher mean somite number compared to females.

    • Conclusions:

    • Embryonic development rate during early neurulation may be influenced by genetic sex.
    • Sex-linked developmental trajectories are observable even at the earliest stages of organogenesis.