Related Experiment Video

Updated: Jul 5, 2025

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

752

Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition

Domingo González-Lamuño1, Francisco Jesús Arrieta-Blanco2, Elena Dios Fuentes3

  • 1Pediatrics Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.

Nutrients
|January 11, 2024
PubMed

Insights

Hyperhomocysteinemia (HHcy) is a risk factor for medical conditions, often diagnosed late. Nutritional strategies and lifestyle changes can manage HHcy and reduce vascular event risks.

Area of Science:

  • Biochemistry
  • Nutritional Science
  • Vascular Medicine

Background:

  • Hyperhomocysteinemia (HHcy) is an independent risk factor for various medical conditions.
  • Diagnosis and management of HHcy face challenges due to low awareness and complex biochemical pathways.
  • Moderate to severe HHcy should be considered in patients with thrombotic vascular events and comorbidities.

Purpose of the Study:

  • To highlight the importance of recognizing and managing HHcy.
  • To outline nutritional and lifestyle interventions for HHcy.
  • To emphasize the role of key nutrients and lifestyle modifications in reducing vascular risks.

Main Methods:

  • Nutritional approach involving dietary strategies and supplementation with vitamins B6, B12, folate, and betaine.
  • Lifestyle modifications including smoking cessation and physical activity.
  • Monitoring plasma homocysteine (Hcy) levels, aiming for concentrations below 50 μmol/L.

Main Results:

  • Nutritional interventions and lifestyle changes support homocysteine (Hcy) remethylation and metabolism.
  • Maintaining low plasma Hcy levels is crucial for mitigating vascular event risk.
  • Personalized dietary plans developed with healthcare professionals are essential.

Conclusions:

  • An integrated approach combining nutritional strategies, supplementation, and lifestyle changes is effective for managing HHcy.
  • Early recognition and proactive management of HHcy can significantly reduce the risk of vascular complications.
  • Collaboration between patients, healthcare providers, and dietitians is key to optimizing HHcy management.

Keywords:
Marfanoid habitusbetaineectopia lentishomocysteinehomocystinuriahyperhomocysteinemiainborn metabolic diseasesremethylationthrombotic eventstranssulfuration

More Related Videos

Isolation of Primary Mouse Retinal Pigmented Epithelium Cells06:21

Isolation of Primary Mouse Retinal Pigmented Epithelium Cells

Published on: November 4, 2022

5.0K
Measurement of Heme Synthesis Levels in Mammalian Cells09:43

Measurement of Heme Synthesis Levels in Mammalian Cells

Published on: July 9, 2015

12.1K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
93
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
160
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.2K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
263
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.1K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.5K