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Bone mass in ankylosing spondylitis.

D M Reid, J J Nicoll, N S Kennedy

    The Journal of Rheumatology
    |October 1, 1986
    PubMed
    Summary
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    Ankylosing spondylitis patients show reduced total body calcium and accelerated bone loss. Some male patients exhibited increased bone mineral content, possibly linked to syndesmophyte formation.

    Area of Science:

    • Rheumatology
    • Bone Metabolism
    • Skeletal Diseases

    Background:

    • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
    • Bone mass abnormalities are increasingly recognized in AS patients, but the underlying mechanisms require further elucidation.

    Purpose of the Study:

    • To quantitatively assess bone mass and bone loss in patients with ankylosing spondylitis.
    • To investigate potential differences in bone parameters between male and female AS patients and controls.

    Main Methods:

    • Measurements included total body calcium, lumbar spine bone mineral content, and metacarpal indices.
    • Longitudinal assessment of bone loss was performed over an 18-month period in a subset of patients.

    Main Results:

    Related Experiment Videos

    • Patients with AS demonstrated a significant reduction in mean total body calcium (5.3%) compared to controls.
    • A mean annual bone loss rate of 2.9% was observed in AS patients over 18 months.
    • Male AS patients showed a significant increase (28%) in bone mineral content, while metacarpal indices were comparable to controls.

    Conclusions:

    • Findings suggest a minor increase in bone turnover in ankylosing spondylitis.
    • The elevated bone mineral content in male patients may be associated with the development of syndesmophytes, characteristic bone spurs in AS.