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Related Experiment Video

Updated: Jul 5, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Pediatric Psoriasis with or without Arthritis: Does It Make a Difference?

Ayelet Ollech1,2, Mor Rotenberg3, Irit Tirosh2,4

  • 1Pediatric Dermatology Unit, Dermatology Department, Sheba Medical Center, Ramat Gan 5262160, Israel.

Journal of Clinical Medicine
|January 11, 2024
PubMed
Summary
This summary is machine-generated.

Pediatric psoriasis patients without arthritis showed greater skin involvement than those with psoriatic arthritis. Psoriasis-only patients also responded better to biologics, offering key insights for pediatric diagnosis.

Keywords:
jointsjuvenile inflammatory arthritispediatricspsoriasispsoriatic arthritissystemic

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Area of Science:

  • Dermatology
  • Pediatric Rheumatology
  • Immunodermatology

Background:

  • Psoriasis and psoriatic arthritis (PsA) can be challenging to diagnose in children, often presenting distinctly or concurrently.
  • Understanding dermatological differences is crucial for accurate pediatric diagnosis and management of these conditions.

Purpose of the Study:

  • To compare dermatological manifestations in pediatric patients with psoriasis versus those with psoriatic arthritis.
  • To identify distinct cutaneous features and treatment responses between these two pediatric groups.

Main Methods:

  • A retrospective case-control study analyzed pediatric patients (≤18 years) diagnosed with psoriasis or psoriatic arthritis between 2011 and 2021.
  • Key parameters included body surface area (BSA) involvement, skin distribution, disease severity, and treatment outcomes (response and side effects).

Main Results:

  • The study included 64 psoriasis-only patients and 29 psoriatic arthritis patients, matched for age and sex.
  • Psoriasis-only patients exhibited significantly higher mean BSA involvement (19.7%) compared to psoriatic arthritis patients (6.1%, p=0.029).
  • Distinct skin distribution patterns were observed, with psoriasis-only patients showing more involvement of extremities, scalp, trunk, and genitals. Methotrexate yielded partial responses in both groups, while biologics were more effective for psoriasis-only patients. Adverse events were infrequent but slightly higher in the psoriasis-only group.

Conclusions:

  • Significant differences exist in cutaneous disease characteristics and severity between pediatric psoriasis and psoriatic arthritis patients.
  • These findings provide valuable insights for improving diagnostic accuracy and understanding disease trajectories in children.
  • Tailoring treatment strategies based on dermatological presentation is essential for optimizing outcomes in pediatric psoriatic disease.