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DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
Published on: October 25, 2017
N-hydroxyaminofluorene: a chemical probe for DNA conformation
Journal of Molecular Biology
|October 5, 1986
Abstract:
The importance of the polymorphism of DNA in the reaction with the chemical carcinogen N-hydroxyaminofluorene is studied by means of a supercoiled plasmid containing an insert of (dC-dG). Immunochemical titration and the determination of the binding spectrum of -aminofluorene adducts show that the carcinogen reacts with B-DNA but not with Z-DNA and that conformational changes of the B-DNA-Z-DNA junctions occur as a function of the superhelical density.
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