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Systemic treatments in atopic dermatitis in children
Deniz İlgün Gürel1, Özge Soyer1, Ümit Murat Şahiner1
1Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Türkiye.
The Turkish Journal of Pediatrics
|January 11, 2024
Summary
Atopic dermatitis (AD) treatment focuses on controlling eczema and inflammation. This review explores systemic agents for childhood AD, targeting inflammation for long-term symptom management.
Area of Science:
- Dermatology
- Immunology
- Pediatrics
Background:
- Atopic dermatitis (AD) is a prevalent inflammatory skin condition causing severe itching and eczema, significantly impacting quality of life.
- Epidermal barrier dysfunction and immune system dysregulation are central to AD pathogenesis, with IgE-mediated sensitization being a key therapeutic target.
Purpose of the Study:
- To provide a comprehensive review of systemic agents utilized in the management of childhood atopic dermatitis.
- To highlight therapeutic strategies that primarily target cutaneous inflammation in pediatric AD.
Main Methods:
- Extensive literature review of systemic therapies for childhood atopic dermatitis.
- Focus on agents targeting inflammatory pathways involved in AD.
Main Results:
- Systemic therapies are essential for children with AD who do not respond adequately to topical treatments.
- Various systemic agents are available, offering options for managing moderate to severe childhood atopic dermatitis.
Conclusions:
- A multi-step approach, tailored to disease severity, is crucial for effective long-term eczema control in children with AD.
- Systemic agents play a vital role in managing childhood atopic dermatitis by addressing underlying inflammation.
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