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Evaluating proxies for motion sickness in rodent.

Fu-Xing Zhang1, Xiao-Hang Xie1, Zi-Xin Guo1

  • 1Department of Human Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, School of Basic Medicine, The Fourth Military Medical University, Xi'an, PR China.

IBRO Neuroscience Reports
|January 11, 2024
PubMed
Summary

Motion sickness (MS) arises from conflicting sensory inputs. Rodent models using pica and conditioned taste aversion/avoidance effectively mimic nausea and emesis, aiding MS research and therapeutics.

Keywords:
Conditioned taste aversionEmesisMotion sicknessNauseaPicaRodent models

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Area of Science:

  • Neuroscience
  • Physiology
  • Pharmacology

Background:

  • Motion sickness (MS) results from sensory conflict between vestibular, visual, and proprioceptive systems.
  • Key symptoms include nausea and emesis, involving complex sensory and sensorimotor pathways.
  • Animal models are crucial for understanding MS pathophysiology.

Purpose of the Study:

  • To review the rationale and evidence supporting rodent pica and conditioned taste aversion/avoidance (CTAver/CTAvoi) as valid indices for nausea and emesis.
  • To discuss experimental considerations and limitations when using these rodent models for MS research.
  • To suggest future research directions utilizing these models.

Main Methods:

  • Review of existing literature on rodent models of motion sickness.
  • Analysis of physiological and behavioral data linking rodent responses to nausea/emesis.
  • Discussion of experimental design and interpretation of results from pica and CTAver/CTAvoi studies.

Main Results:

  • Rodents, despite lacking a vomiting reflex, exhibit pica and CTAver/CTAvoi, which share neural substrates with nausea/emesis.
  • These behaviors serve as reliable proxies for nausea and emesis in preclinical MS research.
  • Pica and CTAver/CTAvoi are valuable for studying neural mechanisms and evaluating anti-emetic therapeutics.

Conclusions:

  • Rodent pica and CTAver/CTAvoi are well-established and validated models for studying nausea and emesis in motion sickness.
  • Careful experimental design and interpretation are essential for maximizing the utility of these models.
  • Further research using these models holds promise for advancing our understanding and treatment of motion sickness.