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Correlation Between Oncostatin M and Acute Ischemic Stroke: A Case-Control Study.

Michael Christian¹, Bo Long¹, Zhanglin Tian¹

¹Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, CHN.

|January 11, 2024

Summary

This summary is machine-generated.

Serum oncostatin M (OSM) levels are elevated in acute ischemic stroke (AIS) patients, correlating with disease severity and risk factors. This finding supports OSM as a potential biomarker for AIS.

Keywords:

acute ischemic stroke biomarker correlation expression oncostatin m serum

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Area of Science:

Biomedical research
Inflammatory response markers
Neurology

Background:

Oncostatin M (OSM) expression is linked to inflammatory diseases.
Its role in acute ischemic stroke (AIS) has not been previously investigated.

Purpose of the Study:

To investigate the correlation between serum OSM levels and various clinical aspects of AIS.
To evaluate OSM as a potential biomarker for AIS.

Main Methods:

A case-control study involving 134 AIS patients and 34 healthy controls.
Serum OSM levels measured using ELISA.
AIS assessed via TOAST classification, NIHSS, MRI, and mRS.

Main Results:

Serum OSM was significantly elevated in AIS patients compared to controls (P<0.001).
OSM levels correlated positively with AIS severity and certain risk factors (age, LDL, PT, SBP).
OSM levels were lower in patients with favorable outcomes.

Conclusions:

Serum OSM expression is altered in AIS and correlates with disease severity and risk factors.
OSM shows potential as a biomarker for assessing AIS.