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Exercise for patients with chronic kidney disease: from cells to systems to function
Jared M Gollie1,2, Alice S Ryan3,4, Sabyasachi Sen5,6
1Research and Development Service, Washington DC Veterans Affairs Medical Center, Washington, District of Columbia, United States.
American Journal of Physiology. Renal Physiology
|January 11, 2024
Summary
Exercise benefits adults with chronic kidney disease (CKD). This review details how exercise training impacts cellular, systemic, and whole-body functions, improving health and function in CKD patients.
Area of Science:
- Nephrology
- Exercise Physiology
- Cellular Biology
Background:
- Chronic kidney disease (CKD) affects 800 million adults globally, presenting complex pathophysiology and management challenges.
- Key risk factors include diabetes, hypertension, age, obesity, diet, inflammation, and inactivity, leading to secondary complications like cardiovascular disease.
- CKD exacerbates obesity and inflammation, impairing cellular homeostasis and reducing health and functional capacity.
Purpose of the Study:
- To comprehensively review the effects of exercise training in patients with CKD.
- To examine exercise adaptations at the cellular (vascular endothelial progenitor cells), systemic (cardiovascular, musculoskeletal, neural), and whole-body (physical function, frailty, fatigability) levels.
Main Methods:
- This is a review article, synthesizing existing research on exercise interventions in CKD.
- The review analyzes data from cellular, systemic, and whole-body perspectives.
Main Results:
- Exercise training demonstrates protective benefits for health and function in aging individuals, including those with CKD.
- Accumulating data support exercise implementation for promoting health and function in CKD patients.
- A comprehensive description of exercise responses and adaptations in CKD is currently lacking.
Conclusions:
- Exercise training positively impacts vascular endothelial progenitor cells, cardiovascular, musculoskeletal, and neural factors in CKD patients.
- Exercise improves physical function, reduces frailty, and mitigates fatigability in individuals with CKD.
- Further understanding of exercise's multifaceted effects is crucial for optimizing CKD management.
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