Related Experiment Video
Updated: Jul 5, 2025

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
PROTACs: Current and Future Potential as a Precision Medicine Strategy to Combat Cancer.
Kailee A Rutherford1,2, Kirk J McManus1,2
1Paul Albrechtsen Research Institute CancerCare Manitoba, Winnipeg, Manitoba, Canada.
Proteolysis targeting chimeras (PROTACs) offer a novel precision medicine approach by degrading disease-causing proteins. This strategy enhances cancer cell killing and holds promise for revolutionizing cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Proteolysis targeting chimeras (PROTACs) are innovative hetero-bifunctional molecules.
- They leverage the ubiquitin proteasome system for targeted protein degradation.
- PROTACs can target previously undruggable proteins, including oncoproteins.
Conclusions:
- PROTACs represent a significant advancement in precision medicine for cancer treatment.
- Further research and overcoming clinical translation challenges are crucial for routine use.
- PROTACs are poised to revolutionize cancer treatment, delay disease onset, and improve patient outcomes.
More Related Videos
08:46A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
Published on: November 12, 2019
10:46A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
Published on: September 13, 2022
Related Concept Videos
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...