Related Experiment Video

Updated: Jul 29, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

30.0K

KRAS modulates immune infiltration levels and survival outcomes in patients with lung adenocarcinoma

Na Li1, Yue Tian2, Xin Liu3

  • 1Harbin Medical University Affiliated Sixth Hospital, Harbin, China.

Medicine
|January 11, 2024
PubMed

Insights

The KRAS oncogene, crucial in lung adenocarcinoma, impacts tumor progression and immune cell infiltration. Its expression is linked to better patient prognosis and tumorigenesis regulation.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • The KRAS oncogene is implicated in tumorigenesis and chemotherapy resistance.
  • Understanding RASs' role in lung adenocarcinoma, including molecular mechanisms and immune infiltration, is limited.

Purpose of the Study:

  • To investigate the expression patterns of RASs in lung adenocarcinoma.
  • To analyze the clinical prognostic potential of RASs.
  • To explore the impact of KRAS on immune infiltration and molecular mechanisms in lung adenocarcinoma.

Main Methods:

  • Gene Expression Profiling Interaction Analysis for RASs expression.
  • Kaplan-Meier analysis for clinical prognosis.
  • TIMER and Cancer Single-cell State Atlas (Cancer SEA) for immune infiltration and molecular mechanisms.

Main Results:

  • KRAS expression levels correlate with favorable prognosis and tumor progression.
  • KRAS expression is associated with various immune cell markers.
  • KRAS influences tumorigenesis and the regulation of multiple oncogenes.

Conclusions:

  • KRAS plays a significant role in the prognosis and immune infiltration of lung adenocarcinoma.
  • KRAS expression is involved in regulating tumorigenesis and oncogenes, impacting patient outcomes.

More Related Videos

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

13.6K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

458

Related Concept Videos

Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...