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Updated: Jul 5, 2025
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Isolation and Characterization of Neutrophils with Anti-Tumor Properties
Published on: June 19, 2015
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Deterministic reprogramming of neutrophils within tumors
Melissa S F Ng1, Immanuel Kwok1, Leonard Tan1
1Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Science (New York, N.Y.)
|January 11, 2024
Summary
Tumor-infiltrating neutrophils undergo irreversible changes, becoming a distinct dcTRAIL-R1+ state that promotes tumor growth. Targeting this neutrophil reprogramming may enhance cancer immunotherapies.
Area of Science:
- Immunology
- Cancer Biology
- Cellular Oncology
Background:
- Neutrophils are crucial in anti-tumor immunity but linked to poor outcomes.
- Cancer research lacks understanding of neutrophil state development and connections.
Purpose of the Study:
- Define common pathways for neutrophil maturation in tumors.
- Investigate mechanisms driving neutrophil state changes in cancer.
Main Methods:
- Epigenetic, transcriptional, and proteomic analyses of tumor-infiltrating neutrophils.
- Comparative studies across multiple cancer types and human samples.
Main Results:
- Neutrophils irreversibly differentiate into a terminal dcTRAIL-R1+ state within tumors.
- These reprogrammed neutrophils reside in hypoxic, glycolytic tumor cores.
- dcTRAIL-R1+ neutrophils exhibit pro-angiogenic functions supporting tumor progression.
Conclusions:
- Neutrophil reprogramming into dcTRAIL-R1+ cells is a conserved cancer trajectory.
- This terminal state promotes tumor growth via pro-angiogenic mechanisms.
- Targeting neutrophil reprogramming offers a strategy to improve cancer immunotherapy efficacy.
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