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Modifiable Risk Factors and Risk of Colorectal and Endometrial Cancers in Lynch Syndrome: A Systematic Review and
Robert F Power1,2, Damien E Doherty3, Imelda Parker4
1Mater Misericordiae University Hospital, Dublin, Ireland.
JCO Precision Oncology
|January 11, 2024
Summary
Obesity increases colorectal cancer risk in Lynch syndrome patients. Lifestyle changes like weight management may aid cancer prevention for this high-risk group.
Area of Science:
- Oncology
- Genetics
- Epidemiology
Background:
- Lynch syndrome is a primary hereditary cause of colorectal and endometrial cancers.
- Modifiable risk factors are established for sporadic cancers but less studied in Lynch syndrome.
Purpose of the Study:
- To investigate associations between modifiable risk factors and cancer risk in individuals with Lynch syndrome.
- To synthesize evidence on lifestyle factors and their impact on Lynch syndrome-related cancers.
Main Methods:
- Systematic literature search of MEDLINE, Embase, and Web of Science for cohort studies.
- Meta-analysis of adjusted hazard ratios for colorectal cancer risk.
- Qualitative synthesis for endometrial cancer risk factors.
Main Results:
- Obesity significantly increased colorectal cancer risk (HR, 2.38).
- Smoking and alcohol intake showed no significant association with colorectal cancer risk.
- Obesity was not linked to increased endometrial cancer risk; hormonal factors and T2DM may play a role.
Conclusions:
- Weight management and physical activity recommendations may be beneficial for cancer prevention in Lynch syndrome.
- Further prospective studies, especially on endometrial cancer, are needed for evidence-based strategies.
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