Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Vascular reactivity in reversible experimental obstructive jaundice.

D Gali, L M Blendis, A Bomzon

The Journal of Surgical Research

|March 1, 1987

Summary

Jaundice alters vascular smooth muscle reactivity to norepinephrine, affecting blood pressure regulation. Bile duct ligation in rats showed lasting changes in vascular response, even after jaundice resolved.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The effects of Bile Acids on Freshly Isolated Rat Glomeruli and Proximal Tubular Fragments.

Toxicology in vitro : an international journal published in association with BIBRA·2010

Same author

Brain natriuretic peptide: is it a predictor of cardiomyopathy in cirrhosis?

Clinical science (London, England : 1979)·2001

Same author

Ursodeoxycholic acid and in vitro vasoactivity of hydrophobic bile acids.

Digestive diseases and sciences·2001

Same author

Vascular smooth muscle cell signaling in cirrhosis and portal hypertension.

Pharmacology & therapeutics·2001

Same author

Oxidative stress and vascular smooth muscle cell function in liver disease.

Pharmacology & therapeutics·2001

Same author

Effects of ascites resolution after successful TIPS on nutrition in cirrhotic patients with refractory ascites.

The American journal of gastroenterology·2001

Area of Science:

Physiology
Pharmacology
Hepatology

Background:

Obstructive jaundice can lead to hypotension and shock in surgical patients.
Vascular smooth muscle reactivity plays a critical role in maintaining blood pressure.

Purpose of the Study:

To investigate the impact of jaundice on the in vitro vascular reactivity of rat thoracic aorta to norepinephrine.
To determine changes in maximal response (Rmax) and norepinephrine concentration for 50% response (ED50) in vascular smooth muscle during and after cholestasis.

Main Methods:

Helically cut thoracic aorta strips from bile duct ligated (BDL) rats and controls were used.
Vascular reactivity to cumulative doses of norepinephrine was measured at various time points post-ligation (1, 3, 6, 14, 28 days).
Liver function, histology, and portal pressure were monitored.

Main Results:

Bile duct ligation induced cholestasis and necrosis, resolving by 14 days.
Age-dependent increases in maximal vascular response (Rmax) were observed in all groups.
Vascular smooth muscle in sham-operated rats showed increased sensitivity to norepinephrine (decreased ED50), a phenomenon absent in BDL rats, where ED50 remained elevated.

Conclusions:

Jaundice, induced by bile duct ligation, alters vascular smooth muscle reactivity to norepinephrine, characterized by reduced sensitivity (higher ED50).
These vascular changes persist even after the resolution of jaundice and cholestasis.
The findings suggest a potential mechanism for hypotension and shock in jaundiced patients, even post-operatively.

Related Experiment Videos