Recent advances in DNA-based probes for photoacoustic imaging
Anusri Anil1, Jyotsna Chaskar1, Avinash B Pawar2
1National Centre for Nanosciences and Nanotechnology, University of Mumbai, Kalina, Mumbai 400098, India.
Journal of Biotechnology
|January 11, 2024
Summary
Photoacoustic imaging (PAI) offers a safer, high-resolution alternative for disease detection. This review explores DNA probes and nanocomposites for enhanced PAI and photothermal therapy (PTT) in cancer diagnostics and treatment.
Area of Science:
- Biomedical Imaging
- Nanotechnology
- Molecular Probes
Background:
- Photoacoustic imaging (PAI) is an advanced biomedical imaging technique.
- PAI combines optical absorption and ultrasound detection for high resolution, contrast, and penetration depth.
- It is a non-ionizing, cost-effective, and healthier alternative to other imaging modalities.
Purpose of the Study:
- To review the application of DNA probes in photoacoustic imaging.
- To discuss modifications and roles of DNA in PAI.
- To explore DNA-based nanocomposites for combined PAI and photothermal therapy (PTT).
Main Methods:
- Literature review of PAI techniques utilizing DNA probes.
- Analysis of DNA modifications for enhanced PAI performance.
- Examination of nanocomposite materials for PAI and PTT applications.
Main Results:
- DNA probes significantly enhance PAI specificity and detection capabilities.
- Various modification strategies improve DNA probe integration and function in PAI.
- DNA-containing nanocomposites demonstrate potential for combined diagnostic and therapeutic applications.
Conclusions:
- DNA probes are crucial for advancing PAI in biomedical applications.
- DNA-based nanocomposites offer a promising platform for integrated cancer detection and therapy.
- Further research into DNA-PAI and PAI-PTT holds significant clinical potential.
