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Simplified Chinese version of the PROMIS Pediatric-25 profile: A validation study among cancer children
Danyu Li1, Yueshi Huang2, Fulei Wu1
1School of Nursing, Fudan University, Shanghai, China.
Insights
The Patient-reported Outcomes Measurement Information System Pediatric-25 Profile (PROMIS-Pediatric-25) is a reliable tool for assessing health in Chinese pediatric cancer patients. This validated instrument aids in evaluating quality of life and symptoms for better clinical care.
Area of Science:
- Pediatric Oncology
- Health Outcomes Research
- Psychometrics
Background:
- Pediatric cancer significantly impacts children's well-being in China.
- Evaluating health-related quality of life (HRQoL) is crucial for clinical care and research.
- The PROMIS-Pediatric-25 is a potential tool for assessing HRQoL in this population.
Purpose of the Study:
- To psychometrically validate the PROMIS-Pediatric-25 among Chinese children with cancer.
- To assess the reliability and validity of the PROMIS-Pediatric-25 in a Chinese pediatric cancer cohort.
- To establish the suitability of PROMIS-Pediatric-25 for clinical and research applications in China.
Main Methods:
- 114 children aged 8-17 with cancer completed the PROMIS-Pediatric-25 and other questionnaires.
- Reliability was assessed using Cronbach's alpha and split-half coefficients.
- Factor structure, Rasch model assumptions, and differential item functioning (DIF) were analyzed.
Main Results:
- Reliability was found to be excellent, with validated factor structures for six domains.
- Rasch model assumptions (unidimensionality, local independence, monotonicity) were met.
- Measurement equivalence was observed, with no significant DIF across gender, diagnosis, or treatment stage.
Conclusions:
- The PROMIS-Pediatric-25 is a reliable and valid instrument for assessing HRQoL in Chinese pediatric cancer patients.
- This tool can be utilized in nursing practice for efficient symptom and function assessment.
- The validated PROMIS-Pediatric-25 supports improved clinical care and research for pediatric cancer in China.
Purpose:
Pediatric cancer is a significant health concern in China, and evaluating the impact of cancer and its treatment on the well-being of young patients is essential for both clinical care and research purposes. This study aimed to psychometrically validate the Patient-reported Outcomes Measurement Information System Pediatric-25 Profile (PROMIS-Pediatric-25) among Chinese children with cancer.
Design And Methods:
We enrolled a group of 114 children living with cancer between the ages of 8 and 17. Each participant completed questionnaires that covered sociodemographic and clinical information and the PROMIS-Pediatric-25. The floor and ceiling effect was examined. Cronbach's alpha and split-half coefficient were examined to determine the reliability. Factor structure was explored by factor analysis. Three assumptions of Rasch model-based item response theory (IRT) were assessed. Differential item functioning (DIF) was investigated concerning factors of gender, diagnosis, and treatment stage.
Results:
The floor or ceiling effects were detected for six domains. The reliability was found to be excellent. Furthermore, the factor structure of these six domains was validated. Our analysis confirmed that the assumptions required for IRT were met with acceptable unidimensionality, local independence, and good monotonicity. Additionally, we observed measurement equivalence, with outstanding levels of DIF across factors such as gender, diagnosis, and treatment stage.
Conclusion:
PROMIS-Pediatric 25 is a highly reliable and valid instrument for evaluating key domains of health-related quality of life in Chinese pediatric cancer patients.
Practice Implication:
Nursing practice could engage the PROMIS-Pediatric 25 for accurate and quick children symptom and function assessment.
