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Related Concept Videos

Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Regulation of Heart Rates01:31

Regulation of Heart Rates

The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...

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Resting heart rate causally affects the brain cortical structure: Mendelian randomization study.

Yinsheng Zhong1, Jun Li1, Yinghui Hong1

  • 1Department of Emergency, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518003, P. R. China.

Cerebral Cortex (New York, N.Y. : 1991)
|January 11, 2024
PubMed
Summary

Resting heart rate (RHR) may causally impact brain structure. Elevated RHR was linked to decreased global surface area and regional changes in cortical thickness, offering insights into the heart-brain axis.

Keywords:
Mendelian randomizationcortical structureheart rate variabilityresting heart rate

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Area of Science:

  • Neuroscience
  • Cardiology
  • Genetics

Background:

  • Observational studies suggest a link between resting heart rate (RHR) and impaired brain cortical structure.
  • The causal nature of this association remains undetermined.

Purpose of the Study:

  • To investigate the potential causal effect of resting heart rate on brain cortical structure using genetic data.
  • To elucidate the relationship between RHR and specific measures of brain structure.

Main Methods:

  • A Two-Sample Mendelian randomization (MR) analysis was employed.
  • Sensitivity analyses including weighted median, MR Pleiotropy residual sum and outlier, and MR-Egger regression were performed to assess heterogeneity and pleiotropy.

Main Results:

  • MR analysis identified a causal relationship between RHR and cortical structures.
  • Elevated RHR was associated with decreased global surface area (SA).
  • Specific regional effects included decreased SA of pars triangularis, decreased thickness (TH) of the paracentral, and increased TH of the superior temporal sulcus banks.

Conclusions:

  • This MR study provides evidence for a causal link between resting heart rate and brain cortical structure.
  • Findings contribute to understanding the heart-brain axis theory by highlighting potential direct causal pathways.