Related Experiment Video
Updated: Jul 5, 2025
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
13.6K
Lung relapse pattern in children with metastatic Wilms tumor
Giulia Fichera1, Gianni Bisogno2,3, Maria Carmen Affinita2,3
1Department of Neuroradiology, Pediatric Radiology Unit, University Hospital of Padova, Padua, Italy.
Pediatric Blood & Cancer
|January 11, 2024
Summary
Pediatric Wilms tumor relapse in the lungs often recurs in the same location as initial metastasis. This finding aids in understanding lung metastasis patterns for better pediatric cancer management.
Area of Science:
- Pediatric Oncology
- Medical Imaging
- Cancer Metastasis
Background:
- Wilms tumor is the most common kidney cancer in children.
- The lungs are the primary site for Wilms tumor metastasis and recurrence.
- Understanding lung relapse patterns is crucial due to a 15% recurrence rate.
Purpose of the Study:
- To investigate the location of pulmonary relapse in pediatric Wilms tumor patients.
- To determine if lung recurrence occurs at the initial site of metastasis or a new location.
Main Methods:
- Retrospective analysis of pediatric Wilms tumor patients with lung relapse.
- Computed tomography (CT) scans were used to detect and map pulmonary metastases.
- Comparison of initial metastasis sites with sites of tumor recurrence.
Main Results:
- Computed tomography (CT) patterns indicate a high probability of lung relapse occurring at the same site as initial metastasis.
- This suggests a predictable pattern in Wilms tumor lung recurrence.
Conclusions:
- Pulmonary relapse in pediatric Wilms tumor frequently recurs in the original metastatic location.
- Findings can inform surveillance strategies and treatment planning for lung metastases.
