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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Related Experiment Video

Updated: Jul 5, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Measuring Progress in Precision Oncology.

Peter Horak1,2, Stefan Fröhling1,2,3

  • 1Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Cancer Discovery
|January 12, 2024
PubMed
Summary
This summary is machine-generated.

Precision oncology has steadily advanced over 20 years, with regulatory approvals of targeted cancer therapies increasing. This progress links comprehensive tumor profiling to molecularly guided cancer drug development and clinical actionability.

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Area of Science:

  • Oncology
  • Genomics
  • Drug Development

Background:

  • Precision oncology aims to tailor cancer treatment to individual molecular profiles.
  • Tracking regulatory approvals of targeted therapies provides a metric for clinical progress.

Discussion:

  • Suehnholz and colleagues analyzed over two decades of regulatory approvals for targeted cancer therapies.
  • This analysis quantifies the increasing actionability of molecular alterations in clinical practice.

Key Insights:

  • There is a positive correlation between identifying therapeutic targets via comprehensive tumor profiling and developing molecularly guided cancer drugs.
  • The study highlights the growing impact of precision oncology in cancer care.

Outlook:

  • Continued advancements in comprehensive tumor profiling are expected to accelerate the discovery of new therapeutic targets.
  • Future drug development will likely focus on further integrating molecular insights into clinical decision-making for cancer patients.