Related Experiment Video
Updated: Jul 5, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Bispecific T-cell Engagers in Metastatic Castration-Resistant Prostate Cancer
Chadi Hage Chehade1, Georges Gebrael1, Neeraj Agarwal1
1Huntsman Cancer Institute, University of Utah (NCI-CCC), Salt Lake City, Utah.
Summary:
To date, immune targeting agents have provided limited benefits in patients with metastatic prostate cancer. Bispecific T-cell engagers, especially targeting STEAP1, have shown encouraging results in preclinical and phase I studies and thus represent a novel and promising treatment option in this setting. See related article by Nolan-Stevaux et al., p. 90 (7). See related article by Kelly et al., p. 76 (8).
Insights
Bispecific T-cell engagers targeting STEAP1 show promise for metastatic prostate cancer. These novel agents offer a new treatment avenue where other immune therapies have had limited success.
Area of Science:
- Oncology
- Immunotherapy
- Prostate Cancer Research
Background:
- Metastatic prostate cancer remains a challenge with limited treatment benefits from current immune targeting agents.
- Novel therapeutic strategies are needed to improve outcomes for patients with advanced disease.
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12:13Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
10:19Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells
Published on: May 12, 2023
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