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Chitosan/PEG-mediated spinal cord fusion after complete dorsal transection in rabbits - functional results at 30 days
Michael Lebenstein-Gumovski1, Tanzila Rasueva2, Alexander Zharchenko3
1Department of Neurology and Neurosurgery, Stavropol State Medical University, Stavropol, Russian Federation.
Background:
The aim was to study functional recovery in experimental animals (rabbits) with transected spinal cords treated with a combination of photo-cross-linked chitosan in a homogeneous mixture with polyethylene glycol (PEG-chitosan).
Methods:
20 rabbits (n = 10 experimental and n = 10 controls) were submitted to complete spinal cord transection at T9. The experimental group received an intraoperative injection of PEG-chitosan. Neurological recovery was assessed using the modified Basso, Beattie, and Bresnahan scale.
Results:
In the experimental group, partial recovery of movements, sensory function, and sphincter control were all observed by postoperative day 30. Paraplegia and anesthesia persisted in the control group; 4 controls died versus none in the test group.
Conclusion:
PEG-chitosan is a candidate for neurological restoration after spinal paralysis.
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