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Published on: August 30, 2020
Pandemic impact on aneurysmal subarachnoid hemorrhage in Peru's high COVID-19 lethality setting: A public
Jose Daniel Flores-Sanchez1, Daniela Alejandra Perez-Chadid2, John Vargas-Urbina1
1Department of Neurosurgery, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru.
Insights
The COVID-19 pandemic led to increased mortality for patients with aneurysmal subarachnoid hemorrhage in Peru. Healthcare resource reallocation may have impacted care for critical non-COVID-19 conditions.
Area of Science:
- Neurology
- Public Health
- Infectious Diseases
Background:
- The COVID-19 pandemic significantly disrupted global healthcare systems.
- Peru faced one of the highest COVID-19 case fatality rates worldwide.
- Aneurysmal subarachnoid hemorrhage (SAH) is a critical neurological emergency.
Purpose of the Study:
- To compare outcomes for aneurysmal subarachnoid hemorrhage (SAH) patients before and during the COVID-19 pandemic in Peru.
- To assess the impact of pandemic-related healthcare changes on SAH patient management and mortality.
- To identify factors associated with increased mortality during the pandemic.
Main Methods:
- Retrospective comparative study of aneurysmal SAH patients.
- Two study periods: 2019 (pre-pandemic) and 2020 (first wave of pandemic).
- Analysis of patient demographics, comorbidities, COVID-19 status, clinical presentation, treatment, and outcomes.
Main Results:
- 114 patients analyzed; 65 in 2019 and 49 in 2020.
- Higher mortality in 2020 (36.7%) compared to 2019 (15.4%).
- Increased complications (sepsis, respiratory failure, acute kidney failure) observed in 2020; no direct link between COVID-19 infection and SAH mortality.
Conclusions:
- Aneurysmal SAH patients faced worse outcomes during the COVID-19 pandemic.
- Potential healthcare resource diversion to COVID-19 may have negatively impacted SAH care.
- Maintaining essential services for non-infectious emergencies during pandemics is crucial.
Background:
The COVID-19 pandemic in 2020 profoundly impacted healthcare worldwide, and Peru was particularly affected, experiencing the highest COVID-19 case fatality rate globally.
Methods:
We conducted a retrospective comparative study of patients presenting with aneurysmal subarachnoid hemorrhage (SAH) at a public Peruvian national referral center specializing in cerebrovascular diseases. Two study periods were considered, one during the first wave of the COVID-19 pandemic and a second identical period in 2019. Variables included patient demographics, comorbidities, COVID-19 infection status, clinical presentation, treatment approaches, and hospital outcomes.
Results:
We analyzed 114 patients with aneurysmal SAH, 65 (57.0%) treated in 2019 and 49 (43.0%) in 2020. The mean time from emergency admission to the day of definitive treatment during 2019 and 2020 was 2.72 and 1.93 days, respectively. Likewise, the mean time from symptom onset to the date of definitive treatment was 6.71 and 7.70 days, respectively. We identified significant associations between complications such as sepsis, respiratory failure, acute kidney failure, and hospital mortality. The proportion of fatalities was significantly higher in 2020 compared to 2019 (36.7% vs. 15.4%, respectively). Interestingly, there was no statistically significant association between COVID-19 infection status and mortality during the 2020 period.
Conclusion:
Patients with aneurysmal SAH treated during the pandemic had a higher proportion of sepsis, respiratory failure, acute kidney failure, and mortality compared to the pre-pandemic period. Reallocating healthcare resources to prioritize COVID-19 patients may have inadvertently neglected or delayed care for patients with other emergency conditions, such as aneurysmal SAH. This highlights the importance of maintaining adequate care for non-infectious emergencies during a pandemic.
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