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Related Experiment Videos

Acute bilateral deafness with nephritis: a human temporal bone study.

N Yanagita, H Yokoi, J Koide

    The Laryngoscope
    |March 1, 1987
    PubMed
    Summary

    This study details temporal bone pathology in a patient with lymphoma and nephritis, revealing severe cochlear damage and profound hearing loss. The findings highlight the impact of systemic disease on inner ear structures.

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    Area of Science:

    • Oto-neurology
    • Pathology
    • Nephrology

    Background:

    • A 37-year-old male patient presented with acute, bilateral, profound sensorineural hearing loss.
    • The patient had a history of low complement nephritis treated with prednisolone.
    • Autopsy revealed non-Hodgkin's lymphoma, membranous proliferative glomerulonephritis, and necrotizing vasculitis.

    Observation:

    • Pathological examination focused on the temporal bone.
    • Significant pathological changes were confined to the cochlear region.
    • The vestibular structures exhibited no discernible pathological alterations.

    Findings:

    • Complete absence of the organ of Corti was noted.
    • Atrophy or disappearance of the stria vascularis occurred in the upper cochlear turns.

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  • Reissner's membrane collapsed in the middle turn, and new bone formation was present in the apical turn.

    • Implications:

    • Systemic diseases like lymphoma and vasculitis can cause severe cochlear damage.
    • Sensorineural hearing loss may be a manifestation of underlying systemic pathology.
    • Further research is needed to understand the mechanisms linking systemic disease to inner ear pathology.