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Related Experiment Videos

Naloxone, naltrexone and body temperature.

R Eikelboom

    Life Sciences
    |March 16, 1987
    PubMed
    Summary

    Naloxone and naltrexone cause dose-dependent body temperature changes in rats, inducing hypothermia followed by hyperthermia. This hypothermic effect remains consistent regardless of the light or dark cycle.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Physiology

    Background:

    • Naloxone and naltrexone are opioid antagonists.
    • Understanding their physiological effects, including thermoregulation, is crucial.

    Purpose of the Study:

    • To investigate the dose-dependent effects of naloxone and naltrexone on body temperature in rats.
    • To compare the time course and potency of these temperature effects.
    • To examine if the hypothermic effect is influenced by the light-dark cycle.

    Main Methods:

    • Male rats were administered varying doses of naloxone and naltrexone (1-30 mg/kg).
    • Body temperature was monitored over time to assess hypothermic and hyperthermic responses.
    • Experiments were conducted during both light and dark phases of the circadian cycle.

    Main Results:

    • Both naloxone and naltrexone produced a dose-dependent hypothermia, followed by a later hyperthermia.
    • The drugs exhibited similar time courses and potencies in their thermoregulatory effects.
    • A high dose (30 mg/kg) of either drug induced equivalent hypothermia, unaffected by the light or dark cycle.

    Conclusions:

    • Naloxone and naltrexone significantly impact rat body temperature in a predictable, dose-dependent manner.
    • The hypothermic effect of these opioid antagonists is robust and not significantly altered by circadian phase.
    • These findings contribute to understanding the complex physiological actions of opioid antagonists.

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