Related Experiment Video
Updated: Jul 5, 2025
Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
Ginsenosides and Tumors: A Comprehensive and Visualized Analysis of Research Hotspots and Antitumor Mechanisms
Demeng Xia1,2,3, Shuo Wang4, Kaiwen Wu5
1Department of Pharmacy, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.
Abstract:
Background: Ginsenoside, the main active constituent of traditional Chinese medicine Ginseng, has been shown to play an important role in the prevention and treatment of cancer. However, the literature as well as the antitumor mechanisms of ginsenosides has not yet been systematically studied. Methods: We screened all relevant literature on ginsenosides and tumors from Web of Science during 2001-2021 and analyzed the extracted terms of these publications by VOSviewer and CiteSpace. DAVID online tool was used to perform Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathways analysis of ginsenoside-related genes. Cytoscape and String software were used to construct the interaction networks of ginsenoside-related genes and corresponding proteins. Results: A total of 919 publications were included in the study. A total of 122 identified keywords were mainly divided into 3 clusters: "pharmacological function research", "functional validation in animal models" and "anti-tumor efficacy and mechanism". The keywords of "oxidative stress" had the strongest citation burst in the past 5 years. A total of 50 genes were identified as ginsenoside-related genes in tumors. They have the function of regulating gene expression and apoptosis, and they are closely related to signaling pathways in cancers. Ginsenoside-related genes form a complex interactional network, in which TP53 and IL-6 are centrally located. Conclusions: We explored and revealed research hotspots related to the ginsenosides and tumors. More precise anti-tumor mechanism research will be promising in the future. TP53 and IL-6 may be the key points to comprehending the anti-tumor mechanism of ginsenosides.
Insights
Ginsenosides show promise in cancer treatment, with research focusing on their antitumor mechanisms. Key genes like TP53 and IL-6 are central to understanding how ginsenosides combat cancer.
Area of Science:
- Phytochemistry
- Oncology
- Bioinformatics
Background:
- Ginsenoside, a key component of Ginseng, is recognized for its role in cancer prevention and treatment.
- Systematic studies on ginsenosides' antitumor mechanisms are lacking.
Purpose of the Study:
- To systematically analyze research trends and identify key mechanisms of ginsenosides in cancer.
- To explore the network of ginsenoside-related genes and their pathways in tumor biology.
Main Methods:
- Bibliometric analysis of 919 publications (2001-2021) using VOSviewer and CiteSpace.
- Gene Ontology and KEGG pathway analysis using DAVID online tool.
- Protein-protein interaction network construction using Cytoscape and String.
Main Results:
- Identified research clusters: pharmacological function, animal model validation, and antitumor efficacy/mechanisms.
- Detected a citation burst for 'oxidative stress' in recent years.
- Identified 50 ginsenoside-related genes involved in gene regulation, apoptosis, and cancer signaling pathways, with TP53 and IL-6 as central nodes.
Conclusions:
- Revealed current research hotspots concerning ginsenosides and tumors.
- Highlighted TP53 and IL-6 as potentially crucial targets for understanding ginsenoside's anticancer effects.
- Suggested future research should focus on precise antitumor mechanisms.
More Related Videos
11:13Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
13:18Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
Published on: March 3, 2023
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:17The Tumor Microenvironment
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:12Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...