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Related Concept Videos

Types of Toxins01:36

Types of Toxins

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
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Teratogenicity01:07

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
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Systems bioengineering approaches for developmental toxicology.

Beatriz Xavier Soares1,2, Cláudia C Miranda1,2,3, Tiago G Fernandes1,2

  • 1Department of Bioengineering and iBB - Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

Computational and Structural Biotechnology Journal
|January 12, 2024
PubMed
Summary
This summary is machine-generated.

Systems bioengineering offers a holistic approach to developmental toxicology, examining how toxic agents affect developing organisms. This method aids in identifying key biological pathways and developing predictive risk models.

Keywords:
Developmental toxicologyHigh-throughput screeningHuman pluripotent stem cellsMathematical modelingSystems bioengineering

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Area of Science:

  • Developmental toxicology
  • Systems biology
  • Bioengineering

Background:

  • Developmental toxicology studies the impact of external agents on developing organisms.
  • Traditional methods may not fully capture complex interactions.
  • Integrating systems biology and bioengineering offers a novel perspective.

Purpose of the Study:

  • To explore the application of systems bioengineering in developmental toxicology.
  • To highlight the benefits of a holistic understanding of toxicant effects.
  • To showcase engineering principles applied to developmental toxicity research.

Main Methods:

  • Reviewing current literature on systems bioengineering in toxicology.
  • Analyzing case studies demonstrating engineering principles in developmental toxicity.
  • Discussing the integration of systems biology and bioengineering concepts.

Main Results:

  • Systems bioengineering provides a holistic view of toxicant interactions.
  • This approach facilitates identification of critical biological pathways.
  • It aids in developing predictive models for developmental toxicity risks.

Conclusions:

  • Systems bioengineering is highly relevant to advancing developmental toxicology.
  • Engineering principles enhance the understanding of complex biological systems.
  • This interdisciplinary approach is crucial for future risk assessment.