Related Experiment Video
Updated: Jul 5, 2025

Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
Examining hypertension risk among Black and White breast cancer survivors
Arnethea L Sutton1,2, Jian He2, Wendy Bottinor3
1Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Insights
Black breast cancer survivors have a significantly higher risk of developing hypertension. Older age and non-metropolitan residence also increase hypertension risk in this population, highlighting needs for targeted surveillance.
Area of Science:
- Oncology
- Cardiology
- Public Health
Background:
- Breast cancer survivors face increased cardiovascular risks.
- Hypertension is an understudied complication in breast cancer survivors.
- Understanding hypertension incidence is crucial for survivor care.
Purpose of the Study:
- To examine hypertension incidence in breast cancer survivors.
- To investigate the association between race and hypertension risk.
- To identify demographic and clinical factors associated with hypertension development.
Main Methods:
- Retrospective cohort study of 664 women with Stages I-III breast cancer.
- Hypertension identified via International Classification of Diseases codes.
- Bivariate and bivariable Cox regression analyses used.
Main Results:
- 45.5% of survivors developed hypertension.
- Black survivors had lower 1-year hypertension-free survival (47%) vs. White survivors (73%).
- Older age (>50) and non-metropolitan residence were significant predictors of hypertension.
Conclusions:
- Older, Black, and non-metropolitan-residing survivors may require enhanced hypertension surveillance.
- Racial and geographic disparities in hypertension risk warrant further investigation.
- Targeted prevention strategies are needed for high-risk breast cancer survivors.
Purpose:
Breast cancer survivors are at increased risk of cardiovascular dysfunction following their diagnosis; however, hypertension remains underexplored within this context. This retrospective cohort study examined the incidence of hypertension in breast cancer survivors and the association of race with hypertension risk among them.
Methods:
Data for this study were abstracted from the electronic health records of women diagnosed with Stages I-III breast cancer. Incident hypertension diagnosis was identified through International Classification of Diseases codes. Bivariate associations were tested using Student's t-test and chi-squared test of independence. Bivariable Cox regression analysis was used to determine demographic and clinical factors that may have been associated with the development of hypertension.
Results:
A total of 664 women were included. Most women were 50 years of age or younger (52.0%), White (33.0% Black), and received a mastectomy (80.6%). Overall, 45.5% of the cohort developed hypertension. The 1-year hypertension-free survival estimates were 47% (95% confidence interval [CI], 41-54) in Black women and 73% (95% CI, 69-77) in White women (p < 0.0001). Besides race, statistically significant predictors of hypertension included: age greater than 50 (vs. ≤50) (adjusted Hazard Ratio [HR]: 1.40; 95% CI, 1.09-1.80) and residing in a non-metropolitan area (vs. metropolitan) (adjusted HR: 1.60; 95% CI, 1.19-2.16).
Conclusions:
This study suggests that breast cancer survivors who are older, Black, or residing in non-metropolitan areas may benefit from added surveillance and hypertension prevention strategies during treatment. Future studies are needed to identify contributors to the observed racial and geographic disparities.
Related Concept Videos
Pre-Procedural Guidelines for Assessing Blood Pressure
Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Factors affecting Blood pressure
Physiological Factors:
Hypertension and Regulation of Blood Pressure
Psychoneuroimmunology: Diabetes and Cancer
Cancer Survival Analysis

