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Updated: Jul 5, 2025

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
06:08

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

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Association of Segment-Specific Pulse Wave Velocity With Vascular Calcification: The ARIC (Atherosclerosis Risk in

Kentaro Ejiri1, Ning Ding2, Esther Kim3

  • 1Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD.

Journal of the American Heart Association
|January 12, 2024
PubMed

Insights

Pulse wave velocity (PWV) measures arterial stiffness and predicts cardiovascular disease. Certain PWV measures, particularly carotid-femoral PWV, can help identify individuals with coronary artery calcium and descending aorta calcification.

Area of Science:

  • Cardiovascular research
  • Vascular medicine
  • Biomedical engineering

Background:

  • Pulse wave velocity (PWV) is a noninvasive indicator of arterial stiffness and a predictor of cardiovascular disease.
  • The relationship between PWV and calcification in various vascular beds requires further investigation.

Purpose of the Study:

  • To quantify the association between PWV and calcification in multiple vascular territories.
  • To determine if PWV can identify individuals with vascular calcification beyond established risk factors.

Main Methods:

  • Analysis of data from 1351 older adults in the ARIC study.
  • Measurement of segment-specific PWVs (e.g., carotid-femoral, brachial-ankle).
  • Assessment of high calcium scores (Agatston score ≥75th percentile) in coronary arteries and aorta.

Main Results:

  • Several PWVs, including carotid-femoral PWV, were significantly associated with coronary artery calcification.
  • PWVs showed the strongest association with descending aorta calcification.
  • Certain PWVs enhanced the identification of coronary artery and descending aorta calcification beyond traditional risk factors.

Conclusions:

  • The association between PWV and vascular calcification differs across arterial segments.
  • Descending aorta calcification is most strongly linked to PWV measurements.
  • Carotid-femoral PWV is particularly useful for identifying individuals with coronary artery and descending aorta calcification.
Abstract

Keywords:
aortic calcificationarterial stiffnesscomputed tomographycoronary artery calciumpulse wave velocityvalvular calcificationvascular calcification

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