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Related Experiment Video

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Inner ear morphology in wild versus laboratory house mice.

Sabrina Renaud1, Léa Amar1, Pascale Chevret1

  • 1Laboratoire de Biométrie et Biologie Evolutive (LBBE), UMR 5558, CNRS, Université Claude Bernard Lyon 1, Université de Lyon, Villeurbanne, France.

Journal of Anatomy
|January 12, 2024
PubMed
Summary

Laboratory mice show significant divergence in semicircular canal morphology compared to wild mice, indicating reduced selection pressure in captivity. This study reveals how reduced mobility impacts inner ear evolution.

Keywords:
Mus musculus domesticusfluctuating asymmetrygeometric morphometricsintraspecific variationmobility reductionsemicircular canalsvestibular system

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Area of Science:

  • Evolutionary biology
  • Comparative anatomy
  • Animal behavior

Background:

  • Semicircular canals are crucial for balance and mobility, exhibiting evolutionary conservatism due to stabilizing selection.
  • Reduced mobility in laboratory settings may release selection pressures, potentially leading to morphological divergence in the inner ear.

Purpose of the Study:

  • To investigate the impact of reduced mobility and captivity on the morphology of semicircular canals in house mice (Mus musculus).
  • To compare variation levels (inter-population, inter-individual, and intra-individual asymmetry) between wild and laboratory mice.

Main Methods:

  • Geometric morphometrics applied to 3D landmark data of semicircular canals from wild mice, their lab-bred offspring, a standard lab strain (Swiss), and hybrids.
  • Quantification of inter-population, inter-individual (disparity), and intra-individual (asymmetry) variation.

Main Results:

  • Wild mice exhibited conserved inner ear morphology, while the laboratory Swiss strain showed significant divergence.
  • Lab-bred wild mice displayed differences from wild relatives, suggesting plastic responses, but this did not explain the lab strain's divergence.
  • Wild mice showed slightly higher inter-individual variation than lab mice; the lab strain occasionally exhibited higher fluctuating asymmetry.

Conclusions:

  • Release of selection in laboratory conditions allows for rapid drift in the conserved semicircular canal structure.
  • Reduced developmental stability may occur in laboratory strains due to decreased selection or other captivity-related factors.
  • Captivity-induced mobility reduction significantly impacts inner ear morphology, with potential implications for understanding evolutionary responses to environmental changes.