Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling the adaptive evolution of halotolerant aceticlastic methanogenesis: Multi-scale responses and energy partition.

Water research·2026
Same author

Milk-derived small extracellular vesicles promote intestinal epithelial and immune development in suckling mice.

Food research international (Ottawa, Ont.)·2026
Same author

Effect of β-Casein Fortification in Milk Protein on Digestion Properties and Release of Bioactive Peptides in a Suckling Rat Pup Model.

Foods (Basel, Switzerland)·2026
Same author

Nano-Sieve-Enabled On-Chip Concentration and Multiplexed Detection of Raman-Dye-Labeled Nanocubes.

bioRxiv : the preprint server for biology·2025
Same author

Food-derived extracellular vesicles: an emerging intervention strategy for inflammatory bowel disease.

Critical reviews in food science and nutrition·2025
Same author

SERS imaging and ICP-MS quantification of the biological uptake of nanoplastics using a dual-detectable model nanomaterial.

Journal of hazardous materials·2025

Related Experiment Video

Updated: Jun 22, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.7K

Self-Assembled Nanocarrier Delivery Systems for Bioactive Compounds.

Yafei Zhang1, Yuning Zhang1, Rui Ding2

  • 1Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.

Small (Weinheim an Der Bergstrasse, Germany)
|January 12, 2024
PubMed
Summary

Self-assembly (SA) methods create nanocarriers (NCs) that overcome bioactive compound (BC) defects. Understanding the SA-structure-function relationship is key for developing advanced NCs for BC delivery.

Keywords:
bioactive compoundsbuilding blocksfunctionself‐assemblystructure

More Related Videos

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.9K
Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

7.9K

Related Experiment Videos

Last Updated: Jun 22, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.7K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.9K
Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

7.9K

Area of Science:

  • Nanotechnology and Materials Science
  • Biochemistry and Molecular Biology
  • Drug Delivery Systems

Background:

  • Bioactive compounds (BCs) possess crucial functions but are limited by inherent defects.
  • Nanocarriers (NCs) offer a promising solution to overcome BC limitations.
  • Self-assembly (SA) is a key method for constructing NCs, offering advantages over chemical synthesis.

Purpose of the Study:

  • To emphasize the SA-structure-function concept for developing SA-based NCs.
  • To explore the conditions, forces, and molecular mechanisms driving SA in proteins, polysaccharides, and lipids.
  • To detail various SA-formed NC structures and their role in overcoming BC defects.

Main Methods:

  • Review and synthesis of existing literature on self-assembly mechanisms.
  • Analysis of the molecular basis of SA for proteins, polysaccharides, and lipids.
  • Categorization and description of diverse SA-derived NC structures.

Main Results:

  • Identified the critical role of SA mechanisms in dictating NC structure and function.
  • Summarized the fundamental SA principles for key biomolecules.
  • Elaborated on how SA-based NCs effectively address the limitations of BCs.

Conclusions:

  • Highlighting the SA-structure-function paradigm is crucial for advancing SA-based NC development.
  • Artificial NCs constructed via SA are significant for effective BC delivery.
  • This approach promises to broaden the application scope of BCs.