Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Caspases01:24

Caspases

12.5K
Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
12.5K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

6.6K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.6K
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

6.4K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.4K
Apoptosis01:30

Apoptosis

11.5K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
11.5K
Autophagic Cell Death01:18

Autophagic Cell Death

3.4K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamins maintain nuclear envelope homeostasis and genome stability.

Nature communications·2026
Same author

A LexAop > UAS > QUAS trimeric plasmid to generate inducible and interconvertible Drosophila overexpression transgenes.

Scientific reports·2022
Same author

Non-apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence.

EMBO reports·2020
Same author

The LMTK-family of kinases: Emerging important players in cell physiology and pathogenesis.

Biochimica et biophysica acta. Molecular basis of disease·2019
Same author

Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma.

Molecular cancer·2018
Same author

LMTK3 confers chemo-resistance in breast cancer.

Oncogene·2018

Related Experiment Video

Updated: Jul 5, 2025

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila
13:21

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

Published on: November 27, 2016

9.1K

Cellular stress management by caspases.

Luis Alberto Baena-Lopez1, Li Wang1, Franz Wendler2

  • 1Sir William Dunn School of Pathology, University of Oxford, Oxford, OX13RE, UK.

Current Opinion in Cell Biology
|January 12, 2024
PubMed
Summary
This summary is machine-generated.

Caspases, enzymes crucial for apoptosis, also manage cellular stress without causing cell death. Understanding these non-lethal roles is key for human health and disease, though caspase therapies face limitations due to incomplete knowledge.

More Related Videos

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.3K
Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

1.4K

Related Experiment Videos

Last Updated: Jul 5, 2025

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila
13:21

In Vivo Biosensor Tracks Non-apoptotic Caspase Activity in Drosophila

Published on: November 27, 2016

9.1K
Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.3K
Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

1.4K

Area of Science:

  • Cellular biology
  • Molecular medicine
  • Biochemistry

Background:

  • Cellular stress is a major factor in human diseases.
  • Dysfunctional cells must be removed via cell death pathways like apoptosis to maintain organ function.
  • Caspases are key proteases in apoptosis.

Purpose of the Study:

  • To discuss the role of caspases as cellular stress managers.
  • To explore the impact of non-lethal caspase functions on human health and disease.
  • To highlight limitations in caspase-based therapies.

Main Methods:

  • Literature review of caspase functions.
  • Analysis of non-apoptotic roles of caspases.
  • Discussion of implications for disease and therapy.

Main Results:

  • Caspases can regulate cellular processes without inducing cell death.
  • Some non-lethal caspase activities may restore cellular balance under stress.
  • Caspase functions extend beyond apoptosis.

Conclusions:

  • Caspases act as crucial cellular stress managers.
  • Further research into non-apoptotic caspase roles is needed for therapeutic development.
  • Current understanding of caspases limits the efficacy of caspase-based therapies.