Dimeric diarylheptanoids with anti-inflammatory activity from Zingiber officinale
Hong-Bin Fang1, Ying-Ying Si1, Hui-Ying Niu1
1School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Abstract:
Two previously undescribed chain diarylheptanoid derivatives (2-3), five previously undescribed dimeric diarylheptanoids (4-8), together with one known cyclic diarylheptanoid (1) were isolated from Zingiber officinale. Their structures were elucidated by extensive spectroscopic analyses (HR-ESI-MS, IR, UV, 1D and 2D NMR) and ECD calculations. Biological evaluation of compounds 1-8 revealed that compounds 2, 3 and 4 could inhibit nitrite oxide and IL-6 production in lipopolysaccharide induced RAW264.7 cells in a dose-dependent manner.
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