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Hedgehog signalling in CD4+ T helper cell polarisation
Joachim Hanna1, Maike de la Roche1
1University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK.
The International Journal of Biochemistry & Cell Biology
|January 12, 2024
Summary
Hedgehog signaling influences T helper cell differentiation, impacting immune responses and diseases. This pathway
Area of Science:
- Immunology
- Cell Biology
- Molecular Signaling
Background:
- CD4+ T cells orchestrate immunity and disease, differentiating into specialized subsets.
- Transcription factors guiding T helper cell lineages are known, but signaling pathways remain unclear.
Approach:
- This review explores the emerging role of the Hedgehog signaling pathway in T helper cell polarization.
- It examines how this classical morphogen pathway impacts T cell differentiation.
Key Points:
- Hedgehog signaling is implicated in T helper cell polarization.
- This pathway offers potential therapeutic targets for immune modulation.
Conclusions:
- Understanding Hedgehog signaling in T helper cells is crucial for managing immune-related conditions.
- Clinically approved Hedgehog inhibitors may modulate T helper cell-driven responses.
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