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Related Experiment Video

Updated: Jul 5, 2025

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

β-hCG secreting uterine PEComa.

Patrick Murphy^1,2, Karla Machlab², Shahd Almohsen^1,3

¹Department of Laboratory Medicine and Pathobiology, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada.

BMJ Case Reports

|January 12, 2024

Summary

This case study details a rare malignant perivascular epithelioid cell tumour (PEComa) secreting beta human chorionic gonadotropin (β-hCG). The patient

Keywords:

Cancer intervention Gynecological cancer Oncology Pathology

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Last Updated: Jul 5, 2025

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

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Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

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Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis

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Published on: November 8, 2024

Area of Science:

Gynecologic Oncology
Pathology
Medical Imaging

Background:

Perivascular epithelioid cell tumours (PEComas) are rare mesenchymal neoplasms.
Malignant PEComas are exceptionally uncommon, with limited understanding of their behavior.
Beta human chorionic gonadotropin (β-hCG) is a hormone typically associated with pregnancy, but can be aberrantly produced by certain tumors.

Observation:

A postmenopausal patient presented with vaginal bleeding and an elevated serum β-hCG.
Pelvic MRI revealed a complex uterine mass with central necrosis.
Surgical pathology confirmed a malignant PEComa.

Findings:

The patient's β-hCG levels normalized post-surgery, suggesting β-hCG secretion by the PEComa.
This represents a rare instance of a β-hCG secreting PEComa, with only one prior report.
β-hCG secreting sarcomas, including PEComas, may be associated with a poorer prognosis.

Implications:

The clinical significance of β-hCG in non-trophoblastic tumors like PEComas requires further investigation.
Understanding the role of β-hCG as a potential biomarker for treatment response and disease activity is crucial.
Additional research is needed to establish β-hCG as a predictive and prognostic biomarker in these rare malignancies.