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Chromosomal abnormalities associated with fetal megacystis.

Chih-Ping Chen¹

¹Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; Institute of Clinical and Community Health Nursing, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan.

Taiwanese Journal of Obstetrics & Gynecology

|January 12, 2024

Summary

Fetal megacystis can indicate chromosomal abnormalities. Understanding these genetic links aids in prenatal diagnosis, genetic counseling, and potential fetal therapies for this condition.

Area of Science:

Medical Genetics
Prenatal Diagnosis
Fetal Medicine

Background:

Fetal megacystis is a condition characterized by an enlarged fetal bladder.
It is associated with a range of congenital anomalies and syndromes.
Chromosomal abnormalities are among the significant potential causes.

Purpose of the Study:

To review and summarize chromosomal abnormalities linked to fetal megacystis.
To provide valuable information for genetic counseling during prenatal diagnosis.
To inform potential fetal therapeutic strategies.

Main Methods:

Literature review of studies on fetal megacystis and chromosomal abnormalities.
Synthesis of reported associations between fetal megacystis and genetic conditions.
Analysis of implications for prenatal genetic counseling and therapy.

Main Results:

Fetal megacystis is associated with various chromosomal abnormalities.
These include aneuploidies and specific genetic syndromes.
The review consolidates known genetic links for clinical reference.

Conclusions:

Chromosomal abnormalities are a key consideration in fetal megacystis.
Accurate prenatal diagnosis of these abnormalities is crucial.
This knowledge supports informed genetic counseling and management decisions.

Keywords:

Chromosomal abnormality Chromosome Fetal megacystis Prenatal diagnosis

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