Short tandem repeats genotyping of gestational choriocarcinoma - our experiences
Lajos Gergely1, Vanda Repiska1, Robert Petrovic2
1Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University Bratislava, Bratislava, Slovakia; Centre for Gestational Trophoblastic Disease of Slovak Republic, Bratislava, Slovakia.
Objective:
This short communication demonstrates how short tandem repeat genotyping can identify the origin of gestational choriocarcinoma.
Materials And Methods:
The origin of gestational choriocarcinoma in our three cases was determined using the short tandem repeats genotyping technique, which involved quantitative fluorescent PCR and fragmentation analysis.
Results:
In Case 1 despite no medical history of molar pregnancy, DNA analysis indicated that the choriocarcinoma originated from a homozygous complete hydatidiform mole. We conclude, that the patient's complete abortion 10 years prior to the choriocarcinoma diagnosis was an undiagnosed complete hydatidiform mole. In Case 2 and Case 3 the clinically presumed origin of choriocarcinoma was confirmed.
Conclusion:
Determining the origin of choriocarcinoma is essential for clinical application, as it affects the FIGO scoring system for gestational trophoblastic neoplasia, which determines the patient's prognosis and treatment approach.
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