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Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters

Abdul Gofir1, Irawan Satriotomo2, Yossy Catarina Budi Nur Syamsah3

  • 1Department of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/ Dr. Sardjito General Hospital, Jalan Farmako Sekip Utara, Sleman, Mlati, Yogyakarta, 55281, Indonesia. gofir@ugm.ac.id.

BMC Neuroscience
|January 12, 2024
PubMed

Insights

Stroke is a serious COVID-19 complication. Loss of consciousness, motor deficits, respiratory distress, and high monocyte counts predict mortality in these patients. The risk increases with multiple coexisting factors.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Stroke is a significant neurological complication of COVID-19, associated with increased morbidity and mortality.
  • Understanding predictors of mortality in COVID-19 stroke patients is crucial for clinical management.
  • This study investigates clinical and laboratory factors associated with mortality in this patient population.

Purpose of the Study:

  • To identify predictors of mortality in patients with acute stroke and confirmed COVID-19.
  • To analyze the association between clinical manifestations, laboratory parameters, and mortality.
  • To inform clinical decision-making and improve outcomes for COVID-19 stroke patients.

Main Methods:

  • A case-control study was conducted at Dr. Sardjito General Hospital, Indonesia (July 2020 - August 2021).
  • Clinical and laboratory data from 72 acute stroke patients with COVID-19 were collected and analyzed.
  • Bivariate and multivariate analyses, including Hazard Ratio (HR) calculations, were performed to determine mortality predictors.

Main Results:

  • The study included 72 COVID-19 stroke patients; most had ischemic stroke and hypertension.
  • Significant predictors of mortality included loss of consciousness (HR=2.68), motor deficit (HR=2.34), respiratory distress (HR=81.51), and elevated monocyte count (HR=1.002).
  • Severe COVID-19 (52.8%), respiratory distress (56.9%), and high mortality rates (58.3%) were observed.

Conclusions:

  • Mortality in COVID-19 patients with stroke is significantly linked to loss of consciousness, motor deficit, respiratory distress, and elevated monocyte count.
  • The presence of multiple risk factors amplifies the risk of mortality.
  • These findings underscore the importance of monitoring these factors for improved patient outcomes.
Abstract

Keywords:
COVID-19MortalityPredictorsStroke

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