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Dextrans, Pullulan and Lentinan, New Scaffold Materials for Use as Hydrogels in Tissue Engineering
Pascal Lienig1, Samhita Banerjee1, Franziska Kenneweg2
1Institute of Organic Chemistry, Leibniz University Hannover, Schneiderberg 1B, 30167, Hannover, Germany.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|January 13, 2024
Summary
Chemically modified dextrans, pullulan, and lentinan form novel hydrogels for biomedical uses. These biocompatible hydrogels, created under physiological conditions, show promise for tissue engineering and cell compatibility studies.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biotechnology
Background:
- Established polysaccharides like hyaluronic acid are used in biomedical applications.
- Limited knowledge exists on chemically modifying polysaccharides into hydrogels under controlled conditions.
- This study addresses the need for novel hydrogel development using polysaccharides.
Purpose of the Study:
- To develop chemically modified polysaccharides for creating novel hydrogels.
- To investigate hydrogel formation under physiological conditions.
- To enhance hydrogel properties for biomedical applications, including tissue engineering.
Main Methods:
- Synthesis of chemically modified dextrans, pullulan, and lentinan.
- Thioether crosslinking using thiol-modified donors and vinylsulfone/maleimide acceptors.
- Coupling of adhesion factors and dyes to hydrogels.
Main Results:
- Successful synthesis and coupling of linker systems onto polysaccharides.
- Hydrogel formation achieved under physiological conditions.
- Characterization of hydrogels for rheological properties, water uptake, permeability, biodegradability, and cytotoxicity.
Conclusions:
- Chemically modified polysaccharides can form functional hydrogels under physiological conditions.
- The developed hydrogels exhibit tunable properties suitable for biomedical applications.
- The incorporation of adhesion factors enhances cell compatibility, broadening potential applications in tissue engineering.
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