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Efficacy and safety of collagen derivatives for osteoarthritis: A trial sequential meta-analysis
Chun-Wei Liang1, Hsiao-Yi Cheng2, Yu-Hao Lee3
1School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
Objective:
To investigate the efficacy and safety of collagen derivatives for osteoarthritis.
Design:
PubMed, Embase, and Cochrane Library were searched till June 2023 for randomized controlled trials (RCTs) investigating collagen derivatives for treating osteoarthritis. Data were independently extracted by two authors. The risk of bias was assessed using the RoB 2 tool. A random-effects meta-analysis was performed within a frequentist framework. The certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations approach.
Results:
A total of 35 RCTs involving 3165 patients were included. The main analysis of the primary outcome was based on 25 RCTs involving 2856 patients. Collagen derivatives exerted small-to-moderate effects on pain alleviation (standardized mean difference [SMD] -0.35, 95% confidence interval [CI] -0.48 to -0.22, moderate certainty) and function improvement (SMD -0.31, 95%CI -0.41 to -0.22, high certainty) compared with the control. Collagen derivatives were safe; they did not increase the risk of withdrawal or adverse events compared with the control. The trial sequential analyses indicated that this study had sufficient statistical power for deriving definitive conclusions, confirming the robustness of our findings.
Conclusions:
Strong evidence supports the efficacy and safety of collagen derivatives for osteoarthritis treatment.
Insights
Collagen derivatives effectively reduce pain and improve function in osteoarthritis patients. This meta-analysis confirms their safety and efficacy, offering strong evidence for treatment.
Area of Science:
- Rheumatology and Orthopedics
- Pharmacology and Therapeutics
Background:
- Osteoarthritis (OA) is a prevalent degenerative joint disease causing pain and functional decline.
- Current OA treatments offer variable efficacy and carry potential risks.
- Collagen derivatives are explored as a therapeutic option for OA management.
Approach:
- A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted.
- Searches were performed in PubMed, Embase, and Cochrane Library up to June 2023.
- Risk of bias, meta-analysis (random-effects model), and certainty of evidence (GRADE) were assessed.
Key Points:
- 35 RCTs with 3165 patients were included in the analysis.
- Collagen derivatives demonstrated small-to-moderate effects on pain alleviation (SMD -0.35, moderate certainty) and function improvement (SMD -0.31, high certainty).
- No significant increase in adverse events or withdrawal rates was observed compared to controls.
Conclusions:
- Strong evidence supports the efficacy of collagen derivatives in managing osteoarthritis symptoms.
- Collagen derivatives are a safe and effective treatment option for osteoarthritis.
- The findings provide robust support for the use of collagen derivatives in clinical practice for OA.
