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Updated: Jul 5, 2025

In Vitro Assay to Study Tumor-macrophage Interaction
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In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

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Role of the ubiquitin-proteasome system on macrophages in the tumor microenvironment

Yue Xiao1, Ruiqian Liu2, Na Li2

  • 1First School of Clinical Medicine, Nanchang University, Nanchang, China.

Journal of Cellular Physiology
|January 14, 2024
PubMed

Insights

Tumor-associated macrophages (TAMs) are crucial in tumors. Targeting the ubiquitin-proteasome system (UPS) in TAMs offers a novel therapeutic strategy for cancer treatment.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Tumor-associated macrophages (TAMs) are key players in the tumor microenvironment, influencing tumor progression through secreted factors.
  • TAM accumulation correlates with poor patient prognosis, highlighting them as therapeutic targets.
  • The ubiquitin-proteasome system (UPS) regulates protein stability and cellular processes, with a complex role in cancer.

Purpose of the Study:

  • To explore the multifaceted roles of the UPS in regulating TAM functions.
  • To investigate the potential of targeting the UPS within TAMs as a cancer therapy.

Main Methods:

  • This review synthesizes current literature on TAM biology and UPS function in cancer.
  • Analysis of studies investigating the interplay between UPS and TAM polarization and function.

Main Results:

  • The UPS significantly influences TAM polarization, cytokine secretion, and overall function.
  • Dysregulation of the UPS in TAMs contributes to tumor development and immune evasion.
  • Targeting specific UPS components in TAMs demonstrates potential for anti-tumor effects.

Conclusions:

  • The UPS plays a critical role in modulating TAM behavior within the tumor microenvironment.
  • Targeting the UPS in TAMs represents a promising and innovative strategy for cancer treatment.
Keywords:
E3 ubiquitin ligasemacrophage polarizationtherapytumor-associated macrophagesubiquitin-proteasome system

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