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Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
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Isolation of Human Islets from Partially Pancreatectomized Patients
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A study on the relationship between malignancy and diabetes.

Sebiha Ozge Duman1, Merve Kayali Sevim2, Nevin Dinccag3

  • 1Istanbul University Oncology Institute, Istanbul, Turkiye.

Clinical Nutrition ESPEN
|January 14, 2024
PubMed
Summary
This summary is machine-generated.

Malignancy and diabetes mellitus (DM) are prevalent health issues. This study examined DM in cancer patients, finding that some overt DM patients had poor follow-up and that cancer treatments can induce DM, necessitating regular glucose monitoring.

Keywords:
CancerDiabetes mellitusObesityRisk

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Area of Science:

  • Oncology
  • Endocrinology
  • Public Health

Background:

  • Malignancy and diabetes mellitus (DM) represent significant global health challenges with increasing prevalence and high morbidity/mortality rates.
  • Understanding the interplay between these conditions is crucial for effective patient management and public health strategies.

Purpose of the Study:

  • To investigate the prevalence of overt DM in individuals diagnosed with malignancy.
  • To evaluate the impact of pre-diagnosis glucose control, DM duration, and treatment on malignancy development and type.
  • To assess the risk of developing DM in non-diabetic cancer patients post-treatment.

Main Methods:

  • A cohort of 469 patients (ages 26-70) with various malignancies were categorized into three groups: pre-existing/concurrent overt DM (Group I, n=97), DM developed during anticancer treatment (Group II, n=17), and non-diabetic malignancy patients (Group III, n=355).

Main Results:

  • Group I patients exhibited higher mean BMI and lower physical activity. A significant proportion of pre-existing DM patients were not adequately followed up or treated. Pancreas surgery and corticosteroid use were noted in patients who developed DM during cancer treatment.

Conclusions:

  • Screening programs for diabetic patients should consider shared risk factors with cancer.
  • Anticancer treatments can precipitate DM development, underscoring the need for regular glucose metabolism monitoring during oncological therapy.