Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteomics01:33

Proteomics

7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K
Genomics02:02

Genomics

36.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Energetic landscapes and fuzzy complexes: Computational targeting of viral intrinsically disordered proteins.

Advances in protein chemistry and structural biology·2026
Same author

Marine-Derived bioactives as precision modulators of molecular targets: Emerging paradigms in therapeutic design.

Advances in protein chemistry and structural biology·2026
Same author

Mitochondrial rescue in Alzheimer's disease: Exploring marine-derived compounds for brain metabolism regulation.

International review of neurobiology·2026
Same author

CRISPR-Cas and Infectious Diseases: A Decade of Translational Advances in Molecular Biotechnology.

Biochemical genetics·2026
Same author

Exploring the impact of haptoglobin gene polymorphisms and severity of sickle cell disease: meta-analysis and gene set enrichment study.

Hematology, transfusion and cell therapy·2026
Same author

Marine-derived polysaccharides and peptides as next-generation immunomodulators: Molecular mechanisms, therapeutic potential, and translational challenges.

Advances in protein chemistry and structural biology·2026

Related Experiment Video

Updated: Jul 5, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.2K

Proteomics and genomics insights on malignant osteosarcoma.

Nachammai Kathiresan1, Chandrabose Selvaraj2, Sangavi Pandian3

  • 1Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, Tamil Nadu, India.

Advances in Protein Chemistry and Structural Biology
|January 14, 2024
PubMed
Summary

Osteosarcoma, a primary bone cancer, involves over-expressed proteins affecting cell behavior and genetic changes. Understanding these molecular aspects can lead to new treatments and improved survival rates for patients.

Keywords:
Bone cancerBone metastasisGenomics biomarkerMolecular pathwaysOsteosarcomaProteomics biomarker

More Related Videos

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.8K
Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

10.1K

Related Experiment Videos

Last Updated: Jul 5, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.2K
Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.8K
Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

10.1K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Osteosarcoma is a primary malignant bone cancer characterized by osteoid production.
  • While less common in adults, understanding its molecular underpinnings is crucial for effective treatment.

Approach:

  • This review integrates findings from proteomics and genomics to explore osteosarcoma's complex biology.
  • It examines the role of differentially expressed proteins and genetic abnormalities in disease development.

Key Points:

  • Over-expressed proteins (e.g., Heat shock proteins, VEGF, Rb1) are linked to cell adhesion, migration, invasion, cell cycle control, and apoptosis in osteosarcoma.
  • Genomic studies reveal chromosomal rearrangements, gene mutations, and amplifications associated with osteosarcoma.
  • These molecular markers show potential as early diagnostic biomarkers and therapeutic targets.

Conclusions:

  • Integrated proteomic and genomic insights enhance the molecular understanding of osteosarcoma.
  • Identifying novel treatment targets through this approach may improve survival rates for osteosarcoma patients.