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Related Concept Videos

Proteomics01:33

Proteomics

7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Updated: Jul 5, 2025

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
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Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

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Functional proteomics based on protein microarray technology for biomedical research.

Pablo Juanes-Velasco1, Carlota Arias-Hidalgo1, Alicia Landeira-Viñuela1

  • 1Department of Medicine and General Cytometry Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.

Advances in Protein Chemistry and Structural Biology
|January 14, 2024
PubMed
Summary
This summary is machine-generated.

This chapter explores proteomics and microarray technology, detailing analytical, functional, and reverse phase microarrays. It highlights the versatility, advantages, and future challenges of these powerful proteomics tools.

Keywords:
AnalyticalFunctionalMicroarraysProteomeProteomicsReverse-phase

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Area of Science:

  • Proteomics
  • Biotechnology
  • Analytical Chemistry

Background:

  • Proteomics has evolved significantly from its inception.
  • Microarray technology has emerged as a key tool in modern proteomics research.
  • Understanding the historical development and applications of proteomics is crucial.

Purpose of the Study:

  • To provide a historical overview of proteomics.
  • To discuss various applications of proteomics, with a specific emphasis on microarray technology.
  • To outline the advantages and future challenges associated with microarray technology in proteomics.

Main Methods:

  • Review of historical data and literature on proteomics.
  • Detailed discussion of different types of microarrays: analytical, functional, and reverse phase.
  • Examination of various case studies demonstrating the versatility of microarray applications.

Main Results:

  • Microarray technology offers significant versatility in proteomics.
  • Analytical, functional, and reverse phase microarrays have diverse applications.
  • Several studies showcase the broad utility of these microarray approaches.

Conclusions:

  • Microarray technology is a versatile and valuable tool in proteomics.
  • Continued advancements are expected, addressing current challenges.
  • The future of proteomics is closely linked to the evolution of microarray platforms.