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[Hepatitis B virus infection status and clinical characteristics in patients with rheumatoid arthritis]

H W Zheng1, Z M Ouyang1, J Pan1

  • 1Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

Zhonghua Yi Xue Za Zhi
|January 14, 2024
PubMed

Insights

Chronic hepatitis B virus (HBV) infection is common in rheumatoid arthritis (RA) patients in China, affecting 10.1% of those screened. This highlights the need for increased HBV screening and management in RA clinical practice.

Area of Science:

  • Rheumatology and Immunology
  • Infectious Diseases Epidemiology
  • Hepatology

Context:

  • Rheumatoid arthritis (RA) patients are a population of interest for infectious disease screening due to potential immune dysregulation and treatment implications.
  • Hepatitis B virus (HBV) infection prevalence varies geographically and can be influenced by demographic factors and vaccination status.
  • Understanding HBV epidemiology in RA patients is crucial for preventing disease progression and managing treatment-related risks.

Purpose:

  • To determine the prevalence of hepatitis B virus (HBV) infection among rheumatoid arthritis (RA) patients in China.
  • To investigate the association between HBV infection status and RA disease characteristics.
  • To assess the burden of chronic HBV infection and its sequelae within the RA patient cohort.

Summary:

  • A cross-sectional study of 1,461 RA patients in China revealed a 10.1% prevalence of chronic HBV infection, significantly higher in males.
  • Resolved HBV infection was observed in 57.6% of patients, while 32.3% had no evidence of HBV infection.
  • Among those with chronic HBV infection, a small proportion had advanced liver disease, including cirrhosis and hepatocellular carcinoma; 1.0% of all RA patients had abnormal liver function.

Impact:

  • The findings underscore that chronic HBV infection is a significant comorbidity in RA patients in China.
  • Results emphasize the critical need for enhanced HBV screening protocols and proactive management strategies within rheumatology clinical practice.
  • This study provides essential epidemiological data to inform public health initiatives and clinical guidelines for RA patient care in HBV-endemic regions.

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