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Metal-Organic Framework-Based Nanomedicines for Ferroptotic Cancer Therapy
Yue Song1, Xinran Xu2, Zheng Wang1
1School of Pharmaceutical Science & Technology, Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, Tianjin University, Tianjin, 300072, China.
Abstract:
As an iron-dependent, non-apoptosis, regulated cell death (RCD) modality, ferroptosis has gained growing attention for cancer therapy. With the development of nanomaterials in the biomedical field, ferroptotic cancer nanomedicine is extensively investigated. Amongst various nanomaterials, metal-organic frameworks (MOFs) are hybridized porous materials consisting of metal ions or clusters bridged by organic linkers. The superior properties of MOFs, such as high porosity and cargo loading, ease of surface modification, and good biocompatibility, make them appealing in inducing or sensitizing ferroptotic cell death. There are remarkable achievements in the field of MOF-based ferroptosis cancer therapy. However, this topic is not reviewed. This review will introduce the fundamentals of MOF and ferroptosis machinery, summarize the recent progress of MOF-based ferroptotic anticancer drug delivery, discuss the benefits and problems of MOFs as vehicles and sensitizers for cancer ferroptosis, and provide the perspective on future research direction on this promising field.
Insights
Metal-organic frameworks (MOFs) show promise for cancer therapy by inducing ferroptosis, a regulated cell death. This review explores MOF-based nanomedicine for ferroptosis, highlighting their benefits and future directions in cancer treatment.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Ferroptosis, an iron-dependent regulated cell death (RCD), is a promising avenue for cancer therapy.
- Nanomaterials, particularly metal-organic frameworks (MOFs), are increasingly investigated for their potential in ferroptosis-based cancer nanomedicine.
Purpose of the Study:
- To review the fundamentals of MOFs and ferroptosis.
- To summarize recent advancements in MOF-based ferroptotic anticancer drug delivery.
- To discuss the advantages and challenges of using MOFs in cancer ferroptosis therapy.
Main Methods:
- Literature review of MOF properties and ferroptosis mechanisms.
- Analysis of MOF-based nanomedicine applications in cancer therapy.
- Discussion of MOFs as drug delivery vehicles and ferroptosis sensitizers.
Main Results:
- MOFs possess advantageous properties like high porosity, cargo loading capacity, and surface modifiability for biomedical applications.
- MOFs are effective in inducing or sensitizing ferroptotic cell death in cancer.
- Significant progress has been made in developing MOF-based ferroptotic anticancer strategies.
Conclusions:
- MOF-based ferroptosis nanomedicine represents a rapidly advancing field with substantial therapeutic potential.
- Further research is needed to address current challenges and optimize MOF applications for cancer ferroptosis therapy.
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