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Comparison of results and age-related changes in establishing reference intervals for CEA, AFP, CA125, and CA199
Juping Chen1,2, Lina Fan3, Zheng Yang3
1Department of Laboratory Medicine, Liangzhu Branch of the First Affiliated Hospital of Zhejiang University, Zhejiang, China.
Abstract:
•The reference intervals calculated using RefineR, Kosmic, TMC, and non-parametric methods are similar.•TMC algorithm is more robust, demonstrates a high pass rate among the four methods and has the ability to automatically isolate outliers.•The reference intervals of CA125 and CA199 showed significant differences between age and sex.
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