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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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miRNAs to the rescue: Reversing heart failure by targeting miR-29

Xinghua Wang1, Iqra Anwar1, Conrad P Hodgkinson1

  • 1Mandel Center for Heart and Vascular Research, and the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA.

Molecular Therapy. Nucleic Acids
|January 15, 2024
PubMed
Abstract

No abstract available in PubMed .

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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