Improving machine learning with ensemble learning on observational healthcare data

Ensemble learning is a powerful technique for improving the accuracy and reliability of prediction models, especially in scenarios where individual models may not perform well. However, combining models with varying accuracies may not always improve the final prediction results, as models with lower accuracies may obscure the results of models with higher accuracies. This paper addresses this issue and answers the question of when an ensemble approach outperforms individual models for prediction. As a result, we propose an ensemble model for predicting patients at risk of postoperative prolonged opioid. The model incorporates two machine learning models that are trained using different covariates, resulting in high precision and recall. Our study, which employs five different machine learning algorithms, shows that the proposed approach significantly improves the final prediction results in terms of AUROC and AUPRC.