Regulation of the high affinity choline transport in locust synaptosomes by adenosine triphosphate

The effect of various nucleotides on the high affinity choline accumulation by synaptosomes from locusts has been studied. Extracellular adenosine triphosphate (ATP) was found to inhibit the transport of choline, whereas the accumulation of gamma-aminobutyric acid was not affected. The ATP-effect could not be mimicked by other purine derivatives, and seems not be mediated by purinergic receptors, but rather hydrolysis of the phosphate appears to be essential.