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Diabetes mellitus and prostate cancer risk: A mendelian randomization analysis

Jian-Xu Yuan1, Qing Jiang1, Sheng-Jie Yu2

  • 1Department of Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

World Journal of Diabetes
|January 15, 2024
PubMed
Abstract

Insights

Diabetes mellitus (DM) increases the risk of prostate cancer (PCa). This study used Mendelian randomization to confirm DM as an independent risk factor for PCa incidence.

Area of Science:

  • Epidemiology
  • Genetics
  • Oncology

Background:

  • The association between diabetes mellitus (DM) and prostate cancer (PCa) requires further investigation.
  • Mendelian randomization (MR) is a robust method for causal inference in epidemiology.

Purpose of the Study:

  • To evaluate the causal relationship between DM and PCa using MR.
  • To determine if DM is a risk factor for developing PCa.

Main Methods:

  • Utilized data from the IEU OpenGWAS project for DM and PCa.
  • Applied three distinct MR methods for analysis.
  • Conducted sensitivity analyses to ensure result validity.

Main Results:

  • Diabetes mellitus was identified as an independent risk factor for prostate cancer.
  • The odds ratio (OR) for PCa associated with DM was 1.018 (95% CI: 1.004-1.032, P=0.014).

Conclusions:

  • Diabetes mellitus significantly increases the incidence rate of prostate cancer.
  • Findings support a causal link between DM and an elevated risk of PCa.
Keywords:
Diabetes mellitusGenome-wide association studyMendelian randomization analysisProstate cancerRisk factors

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